Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21863400 | 0.79 | UHRF1 (0.46) | UHRF1KMT2ACCR1CCR5CCR8 | |
| SCHEMBL27368425 | 0.79 | CYP3A4 (0.50) | UHRF1MAPTMEN1KMT2ACYP2A6 | |
| SCHEMBL9109135 | 0.76 | PCSK9 (0.43) | UHRF1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL28047779 | 0.75 | MAPT (0.50) | MAPTNPC1RAB9APOLBHSD17B10 | |
| SCHEMBL2380248 | 0.75 | MAPT (0.41) | MAPTNPC1RAB9APOLBHSD17B10 | |
| SCHEMBL17828141 | 0.75 | POLB (0.42) | MAPTNPC1RAB9APOLBHSD17B10 | |
| SCHEMBL16720051 | 0.75 | LOX (0.44) | MAPTNPC1RAB9APOLBNPSR1 | |
| SCHEMBL2028222 | 0.75 | GRM5 (0.51) | UHRF1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL21186191 | 0.72 | HRH4 (0.50) | UHRF1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL29984511 | 0.72 | UHRF1 (0.48) | UHRF1CCR1CCR5CCR8RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034018-B2 | Substituted pyrrole mannich bases to combat pain and allergic reactions | GRUENENTHAL GMBH (DE) | 2006-04-25 | — | — | US | disclosed |
| EP-1246799-B1 | SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS | GRUENENTHAL GMBH (DE) | 2003-10-15 | — | — | EP | disclosed |
| US-20030023100-A1 | Substituted pyrrole mannich bases to combat pain and allergic reactions | GRUENENTHAL GMBH (DE) | 2003-01-30 | — | — | US | disclosed |
| EP-1246799-A1 | SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS | Grünenthal GmbH (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001047878-A1 | SUBSTITUTED PYRROLE MANNICH BASES TO COMBAT PAIN AND ALLERGIC REACTIONS | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
| WO-2001047882-A2 | SUBSTANCE LIBRARY WHICH CAN BE OBTAINED BY REACTING ALDEHYDES WITH SECONDARY AMINES, ACID CHLORIDES AND NAPHTHOL, PYRROLE AND/OR INDOLE COMPOUNDS | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030023100-A1 | Substituted pyrrole mannich bases to combat pain and allergic reactions | CRHR1, CNR1, CRHR2 | UHRF1 4074/4885MAPT 3702/4885NPC1 1653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.