Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754093 | 0.83 | EGFR (0.53) | EGFRPLA2G2AKMT2ANR4A2POLB | |
| SCHEMBL6231653 | 0.81 | EGFR (0.48) | EGFRPLA2G2AKMT2ANR4A2POLB | |
| SCHEMBL5755105 | 0.81 | EGFR (0.48) | EGFRPLA2G2AKMT2ANR4A2POLB | |
| SCHEMBL9055766 | 0.80 | NQO2 (0.39) | PLA2G2AKMT2APOLB | |
| SCHEMBL27559336 | 0.78 | EGFR (0.48) | EGFRPLA2G2AKMT2APOLBHPGD | |
| SCHEMBL8574404 | 0.74 | EGFR (0.55) | EGFRPLA2G2AKMT2ANR4A2RXFP1 | |
| SCHEMBL11778609 | 0.73 | PLA2G2A (0.56) | EGFRPLA2G2AKMT2APOLBHPGD | |
| SCHEMBL8571325 | 0.72 | PLA2G2A (0.55) | EGFRPLA2G2AKMT2ANR4A2POLB | |
| SCHEMBL8572727 | 0.72 | EGFR (0.53) | EGFRPLA2G2AKMT2ANR4A2RXFP1 | |
| SCHEMBL2904899 | 0.71 | EGFR (0.46) | EGFRPLA2G2AKMT2ANR4A2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053189-C | pyridazino quinoline compounds | ZENECA LTD (GB) | 2000-06-07 | — | — | CN | disclosed |
| CN-1171787-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1998-01-28 | — | — | CN | disclosed |
| CN-1138332-A | Pyridazinoquinoline compounds | ZENECA LTD (GB) | 1996-12-18 | — | — | CN | disclosed |