Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.48 |
| ▸ | NRAS | P01111 | 10/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 2/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24574006 | 1.00 | FLT3 (0.48) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL24574009 | 0.93 | FLT3 (0.47) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL27362527 | 0.93 | FLT3 (0.47) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL27369163 | 0.92 | FLT3 (0.52) | FLT3NRASIRAK4 | |
| SCHEMBL24573932 | 0.92 | FLT3 (0.52) | FLT3NRASIRAK4 | |
| SCHEMBL24574007 | 0.91 | FLT3 (0.45) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL27369774 | 0.91 | FLT3 (0.45) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL24574036 | 0.85 | FLT3 (0.55) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL24574347 | 0.85 | FLT3 (0.51) | FLT3NRASIRAK4 | |
| SCHEMBL27370144 | 0.85 | FLT3 (0.55) | FLT3NRASIRAK4CCNT1CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250431-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-28 | — | — | WO | disclosed |