Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.47 |
| ▸ | NRAS | P01111 | 9/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.32 |
| ▸ | CCNK | O75909 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.32 |
| ▸ | CDK7 | P50613 | 3/20 | 0.32 |
| ▸ | CCNH | P51946 | 3/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.32 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24574009 | 1.00 | FLT3 (0.47) | FLT3NRASIRAK4SYKCCNT1 | |
| SCHEMBL24574006 | 0.93 | FLT3 (0.48) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL27369767 | 0.93 | FLT3 (0.48) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL27369774 | 0.93 | FLT3 (0.45) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL24574007 | 0.93 | FLT3 (0.45) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL24574347 | 0.92 | FLT3 (0.51) | FLT3NRASIRAK4 | |
| SCHEMBL27369249 | 0.92 | FLT3 (0.51) | FLT3NRASIRAK4 | |
| SCHEMBL24231485 | 0.87 | FLT3 (0.52) | FLT3NRASIRAK4CCNT1CCNK | |
| SCHEMBL27370364 | 0.87 | FLT3 (0.40) | FLT3NRASIRAK4CDK7CCNH | |
| SCHEMBL27368394 | 0.87 | FLT3 (0.40) | FLT3NRASIRAK4CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030908-A1 | MULTI-CYCLIC IRAK1 AND IRAK4 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023250431-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-28 | — | — | WO | disclosed |