Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27515096 | 1.00 | GAA (0.45) | GAAMAPTALDH1A1TP53CYP1A2 | |
| SCHEMBL12620402 | 0.81 | GAA (0.45) | GAAMAPT | |
| SCHEMBL27479513 | 0.81 | GAA (0.45) | GAAMAPT | |
| SCHEMBL27462590 | 0.81 | GAA (0.44) | GAAMAPT | |
| SCHEMBL4999605 | 0.78 | GAA (0.56) | GAAMAPT | |
| SCHEMBL15311795 | 0.73 | HTR2C (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL25758885 | 0.73 | GAA (0.42) | GAAMAPT | |
| SCHEMBL24448407 | 0.72 | GAA (0.45) | GAAMAPT | |
| SCHEMBL19066011 | 0.72 | GAA (0.62) | GAAMAPT | |
| SCHEMBL27930597 | 0.72 | GAA (0.62) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| CN-1142492-A | Substituted N-(indole-2-carbonyl)-glycinamides and derivatives as antidiabetic agents | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |