SCHEMBL27378263

SCHEMBL27378263

COC(=O)c1cc(O[C@H](C)CO[Si](C)(C)C(C)(C)C)cc(OC(F)(F)F)c1

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.37
GCK P35557 12/20 0.35
ALPL P05186 3/20 0.35
GPR139 Q6DWJ6 1/20 0.34
RARG P13631 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
RARA P10276 1/20 0.33
RARB P10826 1/20 0.33
NOTUM Q6P988 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30797822 1.00 MRGPRX4 (0.37) MRGPRX4GCKALPLGPR139RARG
SCHEMBL27377075 1.00 MRGPRX4 (0.37) MRGPRX4GCKALPLGPR139RARG
SCHEMBL30797651 1.00 MRGPRX4 (0.37) MRGPRX4GCKALPLGPR139RARG
SCHEMBL2901233 0.87 CA12 (0.45) GCKRARARARB
SCHEMBL27377080 0.82 FFAR4 (0.31)
SCHEMBL30797693 0.82 FFAR4 (0.31)
SCHEMBL27378268 0.82 FFAR4 (0.31)
SCHEMBL25620963 0.81 ATM (0.43) GCKALPL
SCHEMBL4112699 0.81 LMNA (0.46) MRGPRX4GCKRARARARB
SCHEMBL1427055 0.81 LMNA (0.46) MRGPRX4GCKRARARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024052701-A1 NOVEL COMPOUNDS, COMPOSITIONS AND THERAPEUTIC USES THEREOF CAMBRIDGE ENTERPRISE LIMITED (GB) 2024-03-14 WO disclosed