Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 4/20 | 0.52 |
| ▸ | STS | P08842 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219285 | 1.00 | LMNA (0.64) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL10269454 | 1.00 | LMNA (0.64) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8370295 | 0.91 | LMNA (0.65) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2738512 | 0.90 | LMNA (0.59) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL219557 | 0.90 | LMNA (0.59) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL220122 | 0.90 | LMNA (0.64) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL219118 | 0.89 | LMNA (0.58) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL218765 | 0.89 | LMNA (0.60) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL218764 | 0.89 | LMNA (0.60) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2738546 | 0.89 | LMNA (0.60) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088758-B2 | 17β-hydroxysteroid dehydrogenase type I inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2012-01-03 | — | — | US | disclosed |
| EP-1685150-B1 | NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | SOLVAY PHARM GMBH (DE) | 2008-09-03 | — | — | EP | disclosed |