Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217538 | 0.95 | LMNA (0.46) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL217537 | 0.95 | LMNA (0.46) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL216961 | 0.94 | LMNA (0.46) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL216960 | 0.94 | LMNA (0.46) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL217671 | 0.89 | LMNA (0.49) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL217670 | 0.89 | LMNA (0.49) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL2738605 | 0.89 | LMNA (0.49) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL14087550 | 0.89 | LMNA (0.49) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL218026 | 0.88 | LMNA (0.48) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL218027 | 0.88 | LMNA (0.48) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088758-B2 | 17β-hydroxysteroid dehydrogenase type I inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2012-01-03 | — | — | US | disclosed |
| US-8088758-B2 | 17β-hydroxysteroid dehydrogenase type I inhibitors | ABBOTT PRODUCTS GMBH (DE) | 2012-01-03 | — | — | US | disclosed |
| EP-1685150-B1 | NOVEL 17beta HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | SOLVAY PHARM GMBH (DE) | 2008-09-03 | — | — | EP | disclosed |