Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | MLNR | O43193 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738460 | 1.00 | MEN1 (0.39) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL12188597 | 0.88 | BRD4 (0.40) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL683331 | 0.88 | BRD4 (0.40) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL680790 | 0.86 | MEN1 (0.38) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL681295 | 0.86 | MEN1 (0.38) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL8223337 | 0.85 | SMN1; SMN2 (0.43) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL17030315 | 0.85 | KDM4E (0.42) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL8223319 | 0.85 | SMN1; SMN2 (0.43) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL17030314 | 0.85 | KDM4E (0.42) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL2738472 | 0.83 | NTSR1 (0.41) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-B1 | Hydroxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2015-08-26 | — | — | EP | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2008006040-A1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |