Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.61 |
| ▸ | KIF5B | P33176 | 6/20 | 0.59 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | FBP1 | P09467 | 2/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 6/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | ILK | Q13418 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27719215 | 0.91 | FBP1 (0.60) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL1507462 | 0.87 | RET (0.70) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL4127912 | 0.79 | FBP1 (0.64) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL3172507 | 0.78 | EGFR (0.67) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL27386749 | 0.78 | EGFR (0.62) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL27388530 | 0.78 | EGFR (0.72) | RETKIF5BEGFRFBP1GAK | |
| Hydrochloric Acid SCHEMBL1507513 | 0.78 | EGFR (0.63) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL31747062 | 0.77 | RET (0.74) | RETKIF5BEGFRFBP1ALDH1A1 | |
| SCHEMBL4116471 | 0.76 | EGFR (0.60) | RETKIF5BEGFRFBP1GAK | |
| SCHEMBL20709190 | 0.76 | RET (0.69) | RETKIF5BEGFRFBP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1137037-A | Quinazoline derivatives | PFIZER (US) | 1996-12-04 | — | — | CN | claimed |
| CN-101163468-A | Novel combination of sulfonamide compounds | EISAI R&D MAN CO LTD (JP) | 2008-04-16 | — | — | CN | disclosed |
| CN-1066142-C | Quinazoline derivatives | PFIZER (US) | 2001-05-23 | — | — | CN | disclosed |
| CN-1137037-A | Quinazoline derivatives | PFIZER (US) | 1996-12-04 | — | — | CN | disclosed |