Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684323 | 0.87 | BRD4 (0.44) | SLC6A4SLC6A3FFAR2L3MBTL1POLB | |
| SCHEMBL2738565 | 0.85 | AKT1 (0.43) | SLC6A4SLC6A3FFAR2L3MBTL1CNR2 | |
| SCHEMBL680697 | 0.84 | FFAR2 (0.41) | SLC6A4SLC6A3FFAR2L3MBTL1POLB | |
| SCHEMBL10257267 | 0.83 | FFAR2 (0.41) | SLC6A4SLC6A3FFAR2L3MBTL1CNR2 | |
| SCHEMBL8217387 | 0.82 | CNR2 (0.43) | SLC6A4SLC6A3L3MBTL1CNR2POLB | |
| SCHEMBL2738577 | 0.82 | CNR2 (0.43) | SLC6A4SLC6A3L3MBTL1CNR2POLB | |
| SCHEMBL2738487 | 0.82 | CNR2 (0.43) | SLC6A4SLC6A3L3MBTL1CNR2POLB | |
| SCHEMBL12194476 | 0.81 | FFAR2 (0.38) | SLC6A4SLC6A3FFAR2L3MBTL1CNR2 | |
| SCHEMBL2738877 | 0.78 | SLC6A4 (0.48) | SLC6A4SLC6A3FFAR2L3MBTL1CNR2 | |
| SCHEMBL2738478 | 0.78 | AKT1 (0.42) | FFAR2L3MBTL1CNR2MEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| EP-2399909-A1 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as akt protein kinase inhibitors | Array Biopharma, Inc. (US) | 2011-12-28 | — | — | EP | disclosed |