Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.70 |
| ▸ | JAK2 | O60674 | 12/20 | 0.68 |
| ▸ | JAK3 | P52333 | 12/20 | 0.68 |
| ▸ | JAK1 | P23458 | 6/20 | 0.61 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13644150 | 0.85 | AXL (0.73) | AXLJAK2JAK3JAK1CDK1 | |
| SCHEMBL27387022 | 0.83 | JAK2 (0.57) | AXLJAK2JAK3JAK1KDR | |
| SCHEMBL30788193 | 0.83 | JAK2 (0.57) | AXLJAK2JAK3JAK1KDR | |
| SCHEMBL12813273 | 0.82 | AXL (1.00) | AXLJAK2JAK3JAK1CDK1 | |
| SCHEMBL22098049 | 0.81 | JAK2 (0.68) | JAK2JAK3JAK1KDR | |
| SCHEMBL3620070 | 0.81 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL12813489 | 0.81 | AXL (0.77) | AXLJAK2CDK1KDR | |
| SCHEMBL12964739 | 0.80 | AXL (0.80) | AXLCDK1KDR | |
| SCHEMBL12964726 | 0.80 | AXL (0.70) | AXLJAK2JAK3JAK1CDK1 | |
| SCHEMBL2866901 | 0.80 | JAK2 (0.81) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024035771-A2 | ULK3 INHIBITORS AND USES THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |