Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.57 |
| ▸ | JAK3 | P52333 | 11/20 | 0.57 |
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | MERTK | Q12866 | 5/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30788193 | 1.00 | JAK2 (0.57) | JAK2JAK3AXLLRRK2MERTK | |
| SCHEMBL30788187 | 0.88 | LRRK2 (0.51) | JAK2JAK3AXLLRRK2MERTK | |
| SCHEMBL30788205 | 0.86 | LRRK2 (0.52) | JAK2JAK3LRRK2TTKCHEK1 | |
| SCHEMBL27387131 | 0.83 | AXL (0.70) | JAK2JAK3AXLJAK1KDR | |
| SCHEMBL30788192 | 0.82 | JAK2 (0.70) | JAK2JAK3TTKJAK1MAPK8 | |
| SCHEMBL30788214 | 0.80 | JAK1 (0.47) | JAK2JAK3LRRK2JAK1PTK2 | |
| SCHEMBL27387027 | 0.80 | JAK1 (0.47) | JAK2JAK3LRRK2JAK1PTK2 | |
| SCHEMBL30788218 | 0.75 | JAK1 (0.48) | JAK2JAK3LRRK2TTKJAK1 | |
| SCHEMBL34463174 | 0.75 | LRRK2 (0.51) | LRRK2TTKPTK2 | |
| SCHEMBL30788200 | 0.75 | JAK1 (0.46) | JAK2JAK3LRRK2JAK1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024035771-A2 | ULK3 INHIBITORS AND USES THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |