Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.61 |
| ▸ | JAK3 | P52333 | 12/20 | 0.61 |
| ▸ | LDLR | P01130 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | OPA1 | O60313 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27387280 | 0.90 | JAK2 (0.61) | JAK2JAK3LDLRKITPCSK9 | |
| SCHEMBL30788196 | 0.89 | JAK2 (0.64) | JAK2JAK3LDLRKITPCSK9 | |
| SCHEMBL27387217 | 0.89 | JAK2 (0.64) | JAK2JAK3LDLRKITPCSK9 | |
| SCHEMBL27387032 | 0.79 | JAK2 (0.75) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL27387219 | 0.79 | JAK2 (0.77) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL23275852 | 0.78 | JAK2 (0.56) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL13253312 | 0.77 | JAK2 (0.80) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL2865890 | 0.76 | JAK2 (1.00) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL30052233 | 0.76 | JAK2 (1.00) | JAK2JAK3CDK2JAK1HDAC1 | |
| SCHEMBL30788215 | 0.75 | JAK2 (0.78) | JAK2JAK3CDK2JAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024035771-A2 | ULK3 INHIBITORS AND USES THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |