Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 11/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL684606 | 0.91 | PAX8 (0.41) | PDE2AEPHX2 | |
| SCHEMBL681181 | 0.89 | EPHX2 (0.43) | PDE2AEPHX2IDH1 | |
| SCHEMBL2738791 | 0.88 | PDE2A (0.43) | PDE2AEPHX2 | |
| SCHEMBL20282974 | 0.87 | EPHX2 (0.45) | PDE2AEPHX2 | |
| SCHEMBL2738966 | 0.85 | PDE2A (0.46) | PDE2AEPHX2 | |
| SCHEMBL2738763 | 0.85 | PDE2A (0.46) | PDE2AEPHX2 | |
| SCHEMBL8220500 | 0.85 | PDE2A (0.46) | PDE2AEPHX2 | |
| SCHEMBL2738828 | 0.83 | PDE2A (0.45) | PDE2AEPHX2IDH1 | |
| SCHEMBL12188502 | 0.80 | PDE2A (0.44) | PDE2AEPHX2 | |
| SCHEMBL684604 | 0.80 | PDE2A (0.44) | PDE2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2402325-A2 | Hydroxylated and methoxylated cyclopenta[d]pyrimidines as AKT protein kinase inhibitors | Array Biopharma, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |