Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27790423 | 0.85 | HSD11B1 (0.59) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11213440 | 0.83 | HSD11B1 (0.57) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21115781 | 0.82 | HSD11B1 (0.64) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6664422 | 0.79 | KMT2A (0.52) | HSD11B1GSK3BMAPTCES1ALDH1A1 | |
| SCHEMBL29145590 | 0.78 | HSD11B1 (0.55) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3182347 | 0.77 | KMT2A (0.59) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8664197 | 0.77 | HSD11B1 (0.57) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29145587 | 0.77 | HSD11B1 (0.61) | HSD11B1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27790460 | 0.76 | HSD11B1 (0.50) | HSD11B1MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6203408 | 0.76 | HSD11B1 (1.00) | HSD11B1NPC1RAB9AALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1088704-C | Process for synthesis of benzothiophenes | LILLY CO ELI (US) | 2002-08-07 | — | — | CN | disclosed |
| CN-1230957-A | Process for synthesis of benzothiophenes | LILLY CO ELI (US) | 1999-10-06 | — | — | CN | disclosed |