Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | MC5R | P33032 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL1535383 | 0.82 | TAAR1 (0.66) | TAAR1NPC1POLBALDH1A1TSHR | |
| SCHEMBL550841 | 0.78 | — | — | |
| Maleic Acid SCHEMBL27270673 | 0.78 | TAAR1 (0.59) | TAAR1NPC1POLBALDH1A1TSHR | |
| Glycine SCHEMBL28972096 | 0.77 | TAAR1 (0.74) | TAAR1NPC1POLBALDH1A1TSHR | |
| Acrylic Acid SCHEMBL1199173 | 0.77 | TAAR1 (0.58) | TAAR1NPC1POLBALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL1535324 | 0.77 | TAAR1 (0.79) | TAAR1NPC1POLBALDH1A1TSHR | |
| Bromide SCHEMBL11232675 | 0.77 | TAAR1 (0.79) | TAAR1NPC1POLBALDH1A1TSHR | |
| Phosphoric Acid SCHEMBL27501306 | 0.76 | TAAR1 (0.66) | TAAR1NPC1POLBALDH1A1TSHR | |
| Carbamic Acid SCHEMBL9213299 | 0.75 | TAAR1 (0.77) | TAAR1NPC1POLBALDH1A1TSHR | |
| SCHEMBL921555 | 0.73 | TAAR1 (0.79) | TAAR1NPC1POLBALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1107699-A | Treatment of incontinence | LILLY CO ELI (US) | 1995-09-06 | — | — | CN | disclosed |