⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28023189 | 0.79 | CYP19A1 (0.45) | — | |
| SCHEMBL13404115 | 0.79 | CYP19A1 (0.45) | — | |
| SCHEMBL3825883 | 0.79 | — | — | |
| SCHEMBL27874646 | 0.78 | CYP19A1 (0.39) | — | |
| SCHEMBL2990565 | 0.77 | — | — | |
| SCHEMBL76770 | 0.75 | — | — | |
| SCHEMBL5616569 | 0.75 | — | — | |
| SCHEMBL2456178 | 0.73 | CYP19A1 (0.48) | — | |
| SCHEMBL31582639 | 0.71 | CYP19A1 (0.42) | — | |
| SCHEMBL21634568 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101921236-A | Can be used for treating 2 of neoplastic disease, inflammatory and disorder of immune system, 4-two (phenylamino) pyrimidine | NOVARTIS AG | 2010-12-22 | — | — | CN | claimed |
| CN-101687860-A | Novel n- (8-heteroaryltetrahydronaphtalene-2yl) or n- (5- heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain | ASTRAZENECA AB | 2010-03-31 | — | — | CN | claimed |
| CN-100357275-C | N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases | ASTRAZENECA AB (SE) | 2007-12-26 | — | — | CN | claimed |
| CN-101077865-A | Phthalazines derivatives, preparation method thereof, medicament composition and use | INST MATERIA MEDICA CAMS (CN) | 2007-11-28 | — | — | CN | claimed |
| CN-1886378-A | 1,4-disubstituted isoquinilone derivatives as RAF-kinase inhibitors useful for the treatment of proliferative diseases | NOVARTIS AG (CH) | 2006-12-27 | — | — | CN | claimed |
| CN-1854130-A | Chinazoline derivative, its production, medicinal composition and use | PHARMACEUTICAL INST CHINA ACAD (CN) | 2006-11-01 | — | — | CN | claimed |
| CN-1832929-A | 2, 4-pyrimidinediamines for the treatment of neoplastic diseases, inflammatory diseases and immune system disorders | NOVARTIS AG (CH) | 2006-09-13 | — | — | CN | claimed |
| CN-1788001-A | 2, 4-bis (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2006-06-14 | — | — | CN | claimed |
| CN-1243724-C | Amide derivatives which are useful as cell factor inhibitors | ASTRA ZENECA LTD (SE) | 2006-03-01 | — | — | CN | claimed |
| CN-1639132-A | N-pyrazinyl-phenylsulphonamides and their use in the treatment of chemokine mediated diseases | ASTRAZENECA AB (SE) | 2005-07-13 | — | — | CN | claimed |
| CN-1185211-C | Benzamide derivatives for the treatment of diseases caused by cytokines | ASTRA ZENECA LTD (SE) | 2005-01-19 | — | — | CN | claimed |
| CN-1161352-C | Quinazoline derivatives | — | 2004-08-11 | — | — | CN | claimed |
| CN-1100046-C | Quinazoline derivatives | ZENECA LTD (GB) | 2003-01-29 | — | — | CN | claimed |
| CN-1330631-A | Amide derivatives which are useful as cell factor inhibitors | ASTRA ZENECA LTD (SE) | 2002-01-09 | — | — | CN | claimed |
| CN-1322202-A | Quinazoline derivatives | ASTRA ZENECA N V (SE) | 2001-11-14 | — | — | CN | claimed |
| CN-1321150-A | Amide derivs. useful as inhibitors of production of cytokines | ASTRAZENECA AB (SE) | 2001-11-07 | — | — | CN | claimed |
| CN-1300278-A | Benzamide derivatives for the treatment of diseases caused by cytokines | ASTRA ZENECA LTD (SE) | 2001-06-20 | — | — | CN | claimed |
| CN-1182421-A | Quinazoline derivatives | ZENECA LTD (GB) | 1998-05-20 | — | — | CN | claimed |
| CN-103204781-A | 2, 7-bi-substituted fluorenone derivative and preparation method and application thereof | UNIV WUHAN | 2013-07-17 | — | — | CN | disclosed |
| CN-1085546-A | Aminediol protease inhibitors | SQUIBB & SONS INC (US) | 1994-04-20 | — | — | CN | disclosed |