Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 6/20 | 0.44 |
| ▸ | WEE1 | P30291 | 3/20 | 0.44 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.43 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.43 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.41 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30905495 | 1.00 | PKMYT1 (0.44) | PKMYT1WEE1EPHB3LCKMAP2K3 | |
| SCHEMBL30905494 | 1.00 | PKMYT1 (0.44) | PKMYT1WEE1EPHB3LCKMAP2K3 | |
| SCHEMBL30905482 | 0.84 | PKMYT1 (0.47) | PKMYT1LCKMAP2K3MAP2K6BTK | |
| SCHEMBL27401714 | 0.84 | PKMYT1 (0.47) | PKMYT1LCKMAP2K3MAP2K6BTK | |
| SCHEMBL27397531 | 0.84 | WEE1 (0.44) | PKMYT1WEE1EPHB3LCKMAP2K3 | |
| SCHEMBL30905594 | 0.84 | PKMYT1 (0.40) | PKMYT1WEE1EPHB3LCKBTK | |
| SCHEMBL27397615 | 0.84 | PKMYT1 (0.40) | PKMYT1WEE1EPHB3LCKBTK | |
| SCHEMBL30905544 | 0.83 | GRM2 (0.41) | PKMYT1WEE1ALDH1A1KDM4EGRM2 | |
| SCHEMBL30905590 | 0.83 | PKMYT1 (0.40) | PKMYT1WEE1EPHB3LCKGRM2 | |
| SCHEMBL30905550 | 0.83 | KMT2A (0.46) | PKMYT1WEE1ALDH1A1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |