Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 19/20 | 0.45 |
| ▸ | WEE1 | P30291 | 3/20 | 0.38 |
| ▸ | MYT1 | Q01538 | 2/20 | 0.38 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30905521 | 1.00 | PKMYT1 (0.45) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL30905573 | 0.83 | PKMYT1 (0.42) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL27397363 | 0.83 | PKMYT1 (0.38) | PKMYT1WEE1EPHB3 | |
| SCHEMBL30905608 | 0.83 | PKMYT1 (0.38) | PKMYT1WEE1EPHB3 | |
| SCHEMBL27397362 | 0.83 | PKMYT1 (0.42) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL27387818 | 0.77 | PKMYT1 (0.43) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL30971151 | 0.77 | PKMYT1 (0.43) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL31344847 | 0.77 | PKMYT1 (0.39) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL30905518 | 0.75 | PKMYT1 (0.53) | PKMYT1WEE1MYT1EPHB3CYP2C9 | |
| SCHEMBL30905594 | 0.75 | PKMYT1 (0.40) | PKMYT1WEE1MYT1EPHB3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |