Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 10/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27402374 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL27400191 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL27399143 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL27399142 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL30835883 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL27401236 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL31556527 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL30835918 | 0.90 | TEAD1 (0.55) | TEAD1CYP1A2GPR183MAOBKCNH2 | |
| SCHEMBL27399366 | 0.87 | TEAD1 (0.57) | TEAD1CYP1A2GPR183MAOBHDAC3 | |
| SCHEMBL30836081 | 0.85 | TEAD1 (0.54) | TEAD1MAOBKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4587424-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | Bridgene Biosciences, Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| CN-119894866-A | YAP/TAZ-TEAD oncoprotein inhibitors | 布里奇恩生物科学公司 | 2025-04-25 | — | — | CN | disclosed |
| WO-2024059317-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | BRIDGENE BIOSCIENCES, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2024059317-A1 | YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS | BRIDGENE BIOSCIENCES, INC. (US) | 2024-03-21 | — | — | WO | disclosed |