Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.38 |
| ▸ | LCK | P06239 | 4/20 | 0.38 |
| ▸ | TEC | P42680 | 2/20 | 0.37 |
| ▸ | BMX | P51813 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FRK | P42685 | 1/20 | 0.36 |
| ▸ | BLK | P51451 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27397363 | 0.85 | PKMYT1 (0.38) | BTKLCKTECBMXLIMK1 | |
| SCHEMBL30905608 | 0.85 | PKMYT1 (0.38) | BTKLCKTECBMXLIMK1 | |
| SCHEMBL27400215 | 0.84 | PKMYT1 (0.35) | BTKLCKTECBMXLIMK1 | |
| SCHEMBL27397531 | 0.82 | WEE1 (0.44) | BTKLCKKDM4EPKMYT1WEE1 | |
| SCHEMBL27397409 | 0.81 | PKMYT1 (0.42) | BTKLCKDHODHKDM4EL3MBTL1 | |
| SCHEMBL30905534 | 0.81 | PKMYT1 (0.42) | BTKLCKDHODHKDM4EL3MBTL1 | |
| SCHEMBL27400008 | 0.81 | PKMYT1 (0.36) | BTKLCKFRKACVR1KDM4E | |
| SCHEMBL27400007 | 0.78 | PKMYT1 (0.38) | BTKLCKTECBMXFRK | |
| SCHEMBL30905481 | 0.77 | GRM2 (0.46) | BTKLCKTECBMXLIMK1 | |
| SCHEMBL30905537 | 0.77 | GRM2 (0.39) | BTKTECBMXDHODHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112853-A1 | COMPOUNDS THAT INHIBIT PKMYT1 | EXELIXIS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |