SCHEMBL27399822

SCHEMBL27399822

C=CC(=O)N1CCC(/C=C/c2cccc(C(F)(F)F)c2)CC1

nearest known ligand 0.57

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 2/20 0.57
▸ MAOA P21397 1/20 0.57
▸ TEAD1 P28347 8/20 0.53
▸ DCUN1D1 Q96GG9 1/20 0.52
▸ LMNA P02545 2/20 0.48
▸ CCR2 P41597 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.44
▸ TP53 P04637 1/20 0.44
▸ HPGD P15428 1/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.44
▸ EGFR P00533 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27399824 1.00 MAOB (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL31556553 1.00 MAOB (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL27399677 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL27399679 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL27399675 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL27399676 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL30835885 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL30835834 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL30836049 0.93 TEAD1 (0.57) MAOBMAOATEAD1DCUN1D1LMNA
SCHEMBL30836081 0.88 TEAD1 (0.54) MAOBMAOATEAD1DCUN1D1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4587424-A1 YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS Bridgene Biosciences, Inc. (US) 2025-07-23 — — EP disclosed
CN-119894866-A YAP/TAZ-TEAD oncoprotein inhibitors 布里奇恩生物科学公司 2025-04-25 — — CN disclosed
WO-2024059317-A1 YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS BRIDGENE BIOSCIENCES, INC. (US) 2024-03-21 — — WO disclosed
WO-2024059317-A1 YAP/TAZ-TEAD ONCOPROTEINS INHIBITORS BRIDGENE BIOSCIENCES, INC. (US) 2024-03-21 — — WO disclosed
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