Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14031342 | 0.86 | MME (0.49) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL30552957 | 0.86 | ALDH1A1 (0.47) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL29670786 | 0.85 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL30175156 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL2544527 | 0.84 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL11253834 | 0.84 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL31064905 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL14359921 | 0.83 | DPP4 (0.58) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL2739441 | 0.83 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL2739537 | 0.83 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTPTGS2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512176-B2 | Age inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2016-12-06 | — | — | US | disclosed |
| US-20120252866-A1 | Age Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-10-04 | — | — | US | disclosed |
| EP-1863832-B1 | AGE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-01-04 | — | — | EP | disclosed |
| US-20080249030-A1 | Age Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2008-10-09 | — | — | US | disclosed |
| US-20080249030-A1 | Age Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2008-10-09 | — | — | US | disclosed |
| WO-2006103274-A9 | AGE INHIBITORS | PHARMAMENS (FR) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252866-A1 | Age Inhibitors | CFH, CDKL1, XPNPEP1 | ALDH1A1 2949/4885LMNA 651/4885MAPT 3905/4885 |
| US-20080249030-A1 | Age Inhibitors | CFH, XPA, XPNPEP1 | ALDH1A1 1656/4885LMNA 530/4885MAPT 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.