Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.33 |
| ▸ | HTR7 known ✓ | P34969 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 6/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.34 |
| ▸ | APEX1 | P27695 | 5/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 7/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388176 | 0.87 | POLB (0.40) | POLBL3MBTL1APEX1TDP1RECQL | |
| Hydrochloric Acid SCHEMBL7831304 | 0.86 | HTR2B (0.39) | POLBL3MBTL1APEX1TDP1RECQL | |
| Fumaric Acid SCHEMBL7815875 | 0.83 | POLB (0.40) | POLBL3MBTL1APEX1TDP1RECQL | |
| Maleic Acid SCHEMBL7815865 | 0.83 | POLB (0.40) | POLBL3MBTL1APEX1TDP1RECQL | |
| Fumaric Acid SCHEMBL7822728 | 0.83 | POLB (0.40) | POLBL3MBTL1APEX1TDP1RECQL | |
| SCHEMBL7827018 | 0.81 | SLC9A1 (0.44) | SLC9A1 | |
| SCHEMBL7828105 | 0.79 | SLC9A1 (0.35) | POLBL3MBTL1APEX1TDP1RECQL | |
| SCHEMBL1388003 | 0.78 | SLC9A1 (0.38) | SLC9A1CYP2C9CYP2C19CYP3A4HTR7 | |
| Hydrochloric Acid SCHEMBL7824061 | 0.75 | HTR2B (0.33) | SLC9A1HTR7HTR2B | |
| Guanidine SCHEMBL27403230 | 0.74 | POLB (0.32) | POLBL3MBTL1APEX1TDP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080257-C | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | CN | disclosed |
| CN-1123545-A | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-29 | — | — | CN | disclosed |