Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.67 |
| ▸ | IKZF3 | Q9UKT9 | 15/20 | 0.67 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.67 |
| ▸ | TNF | P01375 | 3/20 | 0.53 |
| ▸ | IL1B | P01584 | 3/20 | 0.53 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.53 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.52 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27404424 | 0.88 | CRBN (0.66) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL22959636 | 0.88 | CRBN (0.66) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404546 | 0.88 | CRBN (0.65) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL30890283 | 0.87 | CRBN (0.65) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL30890233 | 0.87 | CRBN (0.68) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404278 | 0.86 | CRBN (0.71) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL17724160 | 0.85 | CRBN (0.71) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL17724106 | 0.85 | CRBN (0.71) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL17724159 | 0.85 | CRBN (0.71) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL26317784 | 0.85 | CRBN (0.68) | CRBNIKZF3DDB1TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024108009-A1 | DYRK/CLK PROTACS AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2024-05-23 | — | — | WO | disclosed |