Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.66 |
| ▸ | IKZF3 | Q9UKT9 | 14/20 | 0.66 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.66 |
| ▸ | TNF | P01375 | 4/20 | 0.52 |
| ▸ | IL1B | P01584 | 3/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22959668 | 0.92 | TNF (0.61) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404451 | 0.88 | CRBN (0.67) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL22959795 | 0.88 | MAP1LC3B (0.54) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404424 | 0.88 | CRBN (0.66) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404546 | 0.87 | CRBN (0.65) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL30890283 | 0.86 | CRBN (0.65) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL30890233 | 0.86 | CRBN (0.68) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL22959759 | 0.86 | MAP1LC3B (0.53) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404278 | 0.85 | CRBN (0.71) | CRBNIKZF3DDB1TNFIL1B | |
| SCHEMBL27404411 | 0.85 | CRBN (0.63) | CRBNIKZF3DDB1TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11771697-B2 | Small molecule degraders of polybromo-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | CRBN 65/4885IKZF3 282/4885DDB1 395/4885 |
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | CRBN 65/4885IKZF3 282/4885DDB1 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.