Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27503273 | 0.93 | CYP19A1 (0.51) | CYP19A1TBXAS1PRKCZMELKCCNT1 | |
| SCHEMBL30896286 | 0.85 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKMRGPRX4 | |
| SCHEMBL6042697 | 0.85 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKMRGPRX4 | |
| SCHEMBL6114835 | 0.81 | CYP19A1 (0.51) | CYP19A1TBXAS1PRKCZMELKCYP51A1 | |
| SCHEMBL6114785 | 0.79 | CYP19A1 (0.49) | CYP19A1TBXAS1PRKCZMELKHDAC3 | |
| SCHEMBL6114827 | 0.77 | TDP1 (0.53) | CYP19A1TBXAS1TDP1 | |
| SCHEMBL27938396 | 0.77 | TDP1 (0.48) | TDP1 | |
| SCHEMBL29612558 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKCCNT1 | |
| SCHEMBL6947317 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKCCNT1 | |
| SCHEMBL6897234 | 0.77 | CYP19A1 (0.54) | CYP19A1TBXAS1PRKCZMELKMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |
| CN-1077716-A | ANTIVIRAL PEPTIDES | PFIZER (US) | 1993-10-27 | — | — | CN | disclosed |