Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13128928 | 0.90 | MEN1 (0.53) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL2740972 | 0.85 | MAPT (0.58) | SMN1; SMN2MAPTKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL2740999 | 0.83 | MAPT (0.49) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL13128922 | 0.80 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL14161620 | 0.72 | POLB (0.60) | SMN1; SMN2MAPTKMT2AL3MBTL1MEN1 | |
| SCHEMBL13165623 | 0.70 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL15647634 | 0.70 | MAPT (0.60) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL2741007 | 0.69 | MEN1 (0.58) | SMN1; SMN2MAPTKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL25754820 | 0.69 | KMT2A (0.51) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL13128959 | 0.69 | KDM4E (0.54) | LMNASMN1; SMN2MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088772-B2 | Sulfonamides and their use as a medicament | THE GENETICS COMPANY, INC. (CH) | 2012-01-03 | — | — | US | disclosed |