Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1034564 | 0.85 | TSHR (0.68) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL5861172 | 0.84 | TSHR (0.54) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL8582386 | 0.84 | TSHR (0.55) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL2203793 | 0.82 | ALDH1A1 (0.54) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL5193947 | 0.82 | IKBKB (0.60) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL30923332 | 0.82 | ALDH1A1 (0.54) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL27485780 | 0.82 | KDM4E (0.60) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL29076972 | 0.82 | TSHR (0.50) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL27804614 | 0.81 | TSHR (0.56) | TSHRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6601700 | 0.81 | ALDH1A1 (0.54) | TSHRKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101967123-B | 2-cyclopropyl-4-(N-methyl substituted anilino) quinoline compound as well as intermediate, preparation method and application thereof | SHANGHAI INST PHARM INDUSTRY | 2012-06-27 | — | — | CN | disclosed |
| CN-101967123-A | 2-cyclopropyl-4-(N-methyl substituted anilino) quinoline compound as well as intermediate, preparation method and application thereof | SHANGHAI INST PHARM INDUSTRY | 2011-02-09 | — | — | CN | disclosed |
| CN-1093709-A | Quinoline carboxylic acid derivative and method for making thereof | JAPAN NEW FAMACEUTICAL CO LTD (JP) | 1994-10-19 | — | — | CN | disclosed |