Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23012191 | 0.88 | MKNK1 (0.49) | MKNK1MKNK2EIF4EACHEROCK1 | |
| SCHEMBL12803917 | 0.85 | ACHE (0.45) | MKNK1MKNK2EIF4EACHEROCK1 | |
| SCHEMBL4553086 | 0.84 | ACHE (0.55) | MKNK1MKNK2ACHEROCK1SMYD3 | |
| SCHEMBL11898544 | 0.84 | ACHE (0.49) | MKNK1MKNK2ACHEROCK1SMYD3 | |
| SCHEMBL6237457 | 0.81 | ACHE (0.65) | MKNK1MKNK2ACHESMYD3PIM1 | |
| SCHEMBL31330566 | 0.81 | ACHE (0.52) | MKNK1MKNK2EIF4EACHEROCK1 | |
| SCHEMBL21639898 | 0.80 | ACHE (0.44) | MKNK1MKNK2ACHEROCK1BRD4 | |
| SCHEMBL26004326 | 0.80 | ACHE (0.63) | ACHESMYD3BMPR1AACVRL1ACVR1 | |
| SCHEMBL24035877 | 0.80 | ROCK1 (0.44) | MKNK1MKNK2EIF4EACHEROCK1 | |
| SCHEMBL27412015 | 0.79 | ACHE (0.43) | MKNK1MKNK2EIF4EACHEROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740481-B1 | DIHYDROBENZOFURAN AND INDEN ANALOGS AS CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2024-06-26 | — | — | EP | disclosed |