Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | MDM4 | O15151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29445591 | 0.85 | MDM2 (0.59) | MDM2FPR2PTPN1MDM4TP53 | |
| SCHEMBL2304920 | 0.85 | MDM2 (0.59) | MDM2FPR2PTPN1MDM4TP53 | |
| SCHEMBL29397862 | 0.85 | MDM2 (0.59) | MDM2FPR2PTPN1MDM4TP53 | |
| SCHEMBL30686153 | 0.85 | MDM2 (0.59) | MDM2FPR2PTPN1MDM4TP53 | |
| SCHEMBL2304915 | 0.85 | MDM2 (0.59) | MDM2FPR2PTPN1MDM4TP53 | |
| SCHEMBL3724885 | 0.85 | MDM2 (0.59) | MDM2FPR2PTPN1MDM4TP53 | |
| SCHEMBL24633696 | 0.83 | MDM4 (0.46) | MDM2MDM4TP53 | |
| SCHEMBL24633706 | 0.82 | MDM4 (0.43) | MDM2MDM4TP53GPR132 | |
| SCHEMBL20112950 | 0.78 | MDM4 (0.40) | MDM2PTPN1MDM4TP53GPR132 | |
| SCHEMBL3264342 | 0.78 | MDM4 (0.44) | MDM2MDM4TP53CTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024101402-A1 | PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS | 中外製薬株式会社 | 2024-05-16 | — | — | WO | disclosed |