Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24633706 | 0.83 | MDM4 (0.43) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL21978443 | 0.83 | MDM4 (0.58) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL30191325 | 0.83 | MDM4 (0.58) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL21978446 | 0.83 | MDM4 (0.58) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL18614310 | 0.83 | MDM4 (0.58) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL31326463 | 0.83 | MDM4 (0.58) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL27413465 | 0.83 | MDM2 (0.49) | MDM4TP53MDM2 | |
| SCHEMBL10076575 | 0.83 | CASP3 (0.41) | MDM4TP53CASP3 | |
| SCHEMBL21895802 | 0.82 | TLR2 (0.45) | MDM4TP53MDM2CASP3TLR2 | |
| SCHEMBL178799 | 0.82 | KMT2A (0.52) | MDM4TP53MDM2TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022234853-A1 | CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS | 中外製薬株式会社 | 2022-11-10 | — | — | WO | disclosed |