Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.52 |
| ▸ | CSF1R | P07333 | 6/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899495 | 0.97 | EGFR (0.55) | EGFRCSF1RPRMT5KITKCNH2 | |
| SCHEMBL22195118 | 0.86 | KIT (0.61) | EGFRCSF1RPRMT5KITADORA2A | |
| SCHEMBL31565345 | 0.86 | KIT (0.61) | EGFRCSF1RPRMT5KITADORA2A | |
| SCHEMBL16546224 | 0.84 | EGFR (0.51) | EGFRCSF1RKIT | |
| SCHEMBL20493380 | 0.84 | KIT (0.70) | EGFRKIT | |
| SCHEMBL6259087 | 0.84 | EGFR (0.53) | EGFRCSF1RPRMT5KIT | |
| SCHEMBL7498524 | 0.84 | DHFR (0.46) | EGFRCSF1RPRMT5KITDHFR | |
| SCHEMBL1895642 | 0.83 | PRMT5 (0.76) | EGFRCSF1RPRMT5 | |
| SCHEMBL3982045 | 0.83 | KIT (0.59) | EGFRCSF1RKIT | |
| SCHEMBL4071289 | 0.82 | EGFR (0.58) | EGFRCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1100778-C | Pyrrolopyrimidines and process for their preparation | NOVARTIS CO (CH) | 2003-02-05 | — | — | CN | disclosed |
| CN-1194647-A | Pyrrolopyrimidines and processes for preparation thereof | NOVARTIS CO (CH) | 1998-09-30 | — | — | CN | disclosed |