Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.70 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.70 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 2/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.30 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9351391 | 1.00 | CRBN (0.70) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL8467530 | 1.00 | CRBN (0.70) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL20670738 | 1.00 | CRBN (0.70) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL14125456 | 0.96 | CRBN (0.62) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL17395304 | 0.96 | CRBN (0.62) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL17395305 | 0.96 | CRBN (0.62) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL17395306 | 0.96 | CRBN (0.62) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL14125454 | 0.96 | CRBN (0.62) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL17395319 | 0.91 | CRBN (0.56) | CRBNFKBP5OR51E2KDM4EGAA | |
| SCHEMBL14232888 | 0.91 | CRBN (0.56) | CRBNFKBP5OR51E2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160243535-A1 | CATALYST COMPLEX WITH CARBENE LIGAND | MATERIA, INC. | 2016-08-25 | — | — | US | disclosed |
| US-20160243535-A1 | CATALYST COMPLEX WITH CARBENE LIGAND | MATERIA, INC. | 2016-08-25 | — | — | US | disclosed |
| US-9339805-B2 | Catalyst complex with carbene ligand | MATERIA, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9339805-B2 | Catalyst complex with carbene ligand | MATERIA, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9233365-B2 | Catalyst complex with carbene ligand | MATERIA, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-9233365-B2 | Catalyst complex with carbene ligand | MATERIA, INC. (US) | 2016-01-12 | — | — | US | disclosed |
| US-20150202610-A1 | CATALYST COMPLEX WITH CARBENE LIGAND | MATERIA, INC. (US) | 2015-07-23 | — | — | US | disclosed |
| US-20150202610-A1 | CATALYST COMPLEX WITH CARBENE LIGAND | MATERIA, INC. (US) | 2015-07-23 | — | — | US | disclosed |
| US-8859779-B2 | Catalyst complex with carbene ligand | MATERIA, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859779-B2 | Catalyst complex with carbene ligand | MATERIA, INC. (US) | 2014-10-14 | — | — | US | disclosed |
| US-20120004418-A1 | Catalyst Complex With Carbene Ligand | MATERIA, INC. | 2012-01-05 | — | — | US | disclosed |
| US-20120004418-A1 | Catalyst Complex With Carbene Ligand | MATERIA, INC. | 2012-01-05 | — | — | US | disclosed |
| US-7902389-B2 | Catalyst complex with carbene ligand | MATERIA, INC. | 2011-03-08 | — | — | US | disclosed |
| US-7902389-B2 | Catalyst complex with carbene ligand | MATERIA, INC. | 2011-03-08 | — | — | US | disclosed |
| US-20100160642-A1 | Catalyst Complex With Carbene Ligand | UNIVERSITY OF NEW ORLEANS RESEARCH & TECHNOLOGY FOUNDATION, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100160642-A1 | Catalyst Complex With Carbene Ligand | UNIVERSITY OF NEW ORLEANS RESEARCH & TECHNOLOGY FOUNDATION, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-7622590-B1 | Including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand; complexes are highly stable to air, moisture and thermal degradation; designed to efficiently carry out a variety of olefin metathesis reactions | UNIVERSITY OF NEW ORLEANS FOUNDATION (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622590-B1 | Including a metal atom having anionic ligands, at least one nucleophilic carbene ligand, and an alkylidene, vinylidene, or allenylidene ligand; complexes are highly stable to air, moisture and thermal degradation; designed to efficiently carry out a variety of olefin metathesis reactions | UNIVERSITY OF NEW ORLEANS FOUNDATION (US) | 2009-11-24 | — | — | US | disclosed |
| EP-1115491-B1 | CATALYST COMPLEX WITH PHENYLINDENYLIDENE LIGAND | UNIV NEW ORLEANS FOUNDATION (US) | 2009-08-05 | — | — | EP | disclosed |
| US-5936100-A | METAL CARBENE COMPLEXES OF RUTHENIUM OR OSMIUM | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 1999-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004418-A1 | Catalyst Complex With Carbene Ligand | ZC3H18, ZC3HAV1L, PDCD1LG2 | CRBN 523/4885FKBP5 3035/4885OR51E2 517/4885 |
| US-20150202610-A1 | CATALYST COMPLEX WITH CARBENE LIGAND | ZC3HAV1L, PDCD1LG2, ICOSLG | CRBN 416/4885FKBP5 3220/4885OR51E2 332/4885 |
| US-20100160642-A1 | Catalyst Complex With Carbene Ligand | ZC3H18, ZC3HAV1L, PDCD1LG2 | CRBN 523/4885FKBP5 3035/4885OR51E2 517/4885 |
| US-20160243535-A1 | CATALYST COMPLEX WITH CARBENE LIGAND | ZC3HAV1L, PDCD1LG2, ICOSLG | CRBN 416/4885FKBP5 3220/4885OR51E2 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.