ZC3H18

Zinc finger CCCH domain-containing protein 18

0 patent compounds predicted against ZC3H18, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Germline variants in ZC3H18 on Sugi Variant → ClinVar classifications, population frequency, and predictor agreement (AlphaMissense, SaProt, REVEL) Full ZC3H18 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

Clinical trials — most relevant to ZC3H18 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Dose Escalation Study of Zinc Supplementation in Critically Ill Children	PHASE1/PHASE2	COMPLETED
Study of the Beach Regimen on Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)	PHASE2	ACTIVE_NOT_RECRUITING
A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering	PHASE1/PHASE2	COMPLETED
Randomized Clinical Trial: IS Zinc and Zinc Ionophere EGCG as Supplement Improve Outcome of Active Pulmonary Tuberculosis	PHASE1	UNKNOWN
Human Leukocyte Antigen (HLA) - A*2402 Restricted Peptide Vaccine Therapy in Patients With Advanced Esophageal Cancer	PHASE1	COMPLETED
Zeushield Cytotoxic T Lymphocytes (Z-CTLs) for Relapsed or Refractory Non Small Cell Lung Cancer (NSCLC)	EARLY_PHASE1	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma	nan	UNKNOWN
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED
Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)	nan	RECRUITING
Tecfidera Diffusion Tensor Imaging	nan	COMPLETED
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Pigeon Peas (Cajanus Cajan) : a Natural Anti-inflammatory Facilitating Weight Loss in Obese Patients Returning to Sport?	nan	UNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Serum Levels of Some Trace Elements in Hepatocellular Carcinoma Patients	nan	UNKNOWN
NCF Gene & TNFSF4 in SLE Patients	nan	UNKNOWN
PCD New Gene Discovery	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Chi-GVM Regimen for the Treatment of R/R PTCL	nan	UNKNOWN
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Evaluation of CEMIP in Pancreatic Cancer	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ZC3H18 binder may also engage these)

Protein	Name	Similarity
Q0P678	—	1.000	Q0P678 →
Q6TQE1	—	0.998	Q6TQE1 →
Q1LUE5	—	0.991	Q1LUE5 →
Q52KI8	—	0.989	Q52KI8 →
P97868	—	0.989	P97868 →
PRRC2A	Protein PRRC2A	0.988	landscape →
Q8IYB3	—	0.987	Q8IYB3 →
Q5TM26	—	0.987	Q5TM26 →
Q5ZMJ9	—	0.987	Q5ZMJ9 →
Q14AX6	—	0.987	Q14AX6 →
P30415	—	0.987	P30415 →
Q9Y2H5	—	0.986	Q9Y2H5 →
Q9D824	—	0.986	Q9D824 →
Q14151	—	0.986	Q14151 →
Q5R5Q2	—	0.986	Q5R5Q2 →
Q3MJK5	—	0.986	Q3MJK5 →
Q15424	—	0.986	Q15424 →
Q9VWN4	—	0.986	Q9VWN4 →
Q80TZ9	—	0.986	Q80TZ9 →
Q6PEI3	—	0.986	Q6PEI3 →
YTHDC1	YTH domain-containing protein 1	0.985	landscape →
Q3UC65	—	0.985	Q3UC65 →
Q69ZA1	—	0.985	Q69ZA1 →
Q66J90	—	0.985	Q66J90 →
Q5XJD3	—	0.985	Q5XJD3 →
E1BB52	—	0.985	E1BB52 →
SETD1A	Histone-lysine N-methyltransferase SETD1A	0.985	landscape →
Q3UMU9	—	0.984	Q3UMU9 →
Q7Z4V5	—	0.984	Q7Z4V5 →
Q62901	—	0.984	Q62901 →