Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.59 |
| ▸ | JAK1 | P23458 | 15/20 | 0.59 |
| ▸ | JAK2 | O60674 | 8/20 | 0.59 |
| ▸ | TYK2 | P29597 | 7/20 | 0.59 |
| ▸ | CDC7 | O00311 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | PAK4 | O96013 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.56 |
| ▸ | CLK2 | P49760 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711654 | 1.00 | JAK3 (0.59) | JAK3JAK1JAK2TYK2CDC7 | |
| SCHEMBL27419743 | 0.94 | JAK3 (0.50) | JAK3JAK1JAK2TYK2CDC7 | |
| SCHEMBL27426135 | 0.90 | JAK3 (0.57) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL27414995 | 0.90 | JAK3 (0.61) | JAK3JAK1JAK2TYK2CDC7 | |
| SCHEMBL31711631 | 0.90 | JAK3 (0.61) | JAK3JAK1JAK2TYK2CDC7 | |
| SCHEMBL27417586 | 0.90 | JAK3 (0.49) | JAK3JAK1JAK2TYK2CDC7 | |
| SCHEMBL31711648 | 0.89 | JAK3 (0.57) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL27414802 | 0.89 | JAK3 (0.57) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL27426137 | 0.89 | JAK3 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL27415405 | 0.89 | JAK3 (0.57) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137548-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2024-06-27 | — | — | WO | disclosed |