Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.49 |
| ▸ | JAK1 | P23458 | 10/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27419743 | 0.91 | JAK3 (0.50) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27417930 | 0.91 | JAK1 (0.52) | JAK3JAK1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL27417349 | 0.90 | JAK3 (0.47) | JAK3JAK1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL27294980 | 0.90 | SMN1; SMN2 (0.44) | JAK3SMN1; SMN2ALDH1A1NPC1PKM | |
| SCHEMBL31711654 | 0.90 | JAK3 (0.59) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27414876 | 0.90 | JAK3 (0.59) | JAK3JAK1TYK2JAK2ALK | |
| SCHEMBL27417192 | 0.87 | JAK3 (0.49) | JAK3JAK1SMN1; SMN2TYK2JAK2 | |
| SCHEMBL27294412 | 0.87 | ALDH1A1 (0.47) | JAK1SMN1; SMN2ALDH1A1NPC1PKM | |
| SCHEMBL27294154 | 0.85 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1NPC1PKMRAB9A | |
| SCHEMBL31711633 | 0.84 | MET (0.46) | JAK3JAK1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137548-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2024-06-27 | — | — | WO | disclosed |