Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367335 | 0.98 | DPP4 (0.52) | DPP4PPARAPDCD1CD274CA12 | |
| Ethane SCHEMBL1275986 | 0.96 | DPP4 (0.50) | DPP4PPARAPDCD1CD274CA12 | |
| Phosphine SCHEMBL27550721 | 0.96 | DPP4 (0.50) | DPP4PPARAPDCD1CD274CA12 | |
| SCHEMBL28825457 | 0.96 | DPP4 (0.50) | DPP4PPARAPDCD1CD274CA12 | |
| SCHEMBL12610868 | 0.94 | PPARA (0.49) | DPP4PPARAPDCD1CD274CA12 | |
| SCHEMBL15391163 | 0.94 | PPARA (0.49) | DPP4PPARAPDCD1CD274CA12 | |
| SCHEMBL28804323 | 0.94 | PPARA (0.49) | DPP4PPARAPDCD1CD274CA12 | |
| SCHEMBL27277466 | 0.92 | DPP4 (0.47) | DPP4PPARAPDCD1CD274CA12 | |
| SCHEMBL27835204 | 0.92 | PPARA (0.48) | DPP4PPARAPDCD1CD274CA12 | |
| Cyanide SCHEMBL28342491 | 0.92 | DPP4 (0.47) | DPP4PPARAPDCD1CD274CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109104862-A | 4, 9-dioxo-4, 9-dihydronaphtho [2,3-b ] furan-3-carboxamide derivatives and their use for the treatment of proliferative and infectious diseases | 中央研究院 | 2018-12-28 | — | — | CN | disclosed |
| CN-101668738-B | Pleuromutilin derivatives for the treatment of microbial mediated diseases | NABRIVA THERAPEUTICS AG (AT) | 2014-10-15 | — | — | CN | disclosed |
| CN-101759645-B | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2014-06-25 | — | — | CN | disclosed |
| CN-102459162-B | Novel cyclopentane derivatives | HOFFMANN LA ROCHE | 2014-01-08 | — | — | CN | disclosed |
| CN-102803259-A | 1H-Imidazo[4, 5-c]quinolinone compounds, useful for the treatment of proliferative diseases | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |
| CN-102686587-A | Azaindole glucokinase activators | HOFFMANN LA ROCHE | 2012-09-19 | — | — | CN | disclosed |
| CN-102574807-A | Spiropiperidine compounds and their use in the treatment of diabetes | LILLY CO ELI | 2012-07-11 | — | — | CN | disclosed |
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |
| CN-102459162-A | Novel cyclopentane derivatives | HOFFMANN LA ROCHE | 2012-05-16 | — | — | CN | disclosed |
| CN-1759118-B | Diazepinoindole derivatives as kinase inhibitors | PFIZER | 2010-12-08 | — | — | CN | disclosed |
| CN-101668738-A | Pleuromutilin derivatives for the treatment of microbial mediated diseases | NABRIVA THERAPEUTICS AG | 2010-03-10 | — | — | CN | disclosed |
| CN-100482639-C | N-bisaryl- and N-aryl-cycloalkylidenyl-alpha-hydroxy-and alpha-alkoxy acid amides | SYNGENTA PARTICIPATIONS AG (CH) | 2009-04-29 | — | — | CN | disclosed |
| CN-100420688-C | Pyrimido[4,5-d]pyrimidine derivatives with anticancer activity | HOFFMANN LA ROCHE (CH) | 2008-09-24 | — | — | CN | disclosed |
| CN-100376564-C | Substituted heterocyclic benzoeycloalkenes and the use thereof as substances having analgesic effect | GRUENENTHAL CHEMIE (DE) | 2008-03-26 | — | — | CN | disclosed |
| CN-1759118-A | Diazepinoindole derivatives as kinase inhibitors | PFIZER (US) | 2006-04-12 | — | — | CN | disclosed |
| CN-1711264-A | Pyrimido[4,5-d]pyrimidine derivatives with anticancer activity | HOFFMANN LA ROCHE (CH) | 2005-12-21 | — | — | CN | disclosed |
| CN-1671651-A | N-bisaryl- and N-aryl-cycloalkylidenyl-alpha-hydroxy-and alpha-alkoxy acid amides | SYNGENTA PARTICIPATIONS AG (CH) | 2005-09-21 | — | — | CN | disclosed |
| CN-1221743-A | Substituted heterocyclic benzoeycloalkenes and the use thereof as substances having analgesic effect | GRUENENTHAL CHEMIE (DE) | 1999-07-07 | — | — | CN | disclosed |
| CN-1086825-A | Three ring and tetracyclic compounds | HOFFMANN LA ROCHE (CH) | 1994-05-18 | — | — | CN | disclosed |