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Sugi Predict / Compounds / SCHEMBL27428515

SCHEMBL27428515

SCHEMBL27428515

COc1cc(OC)cc(-c2cc3cnc(Nc4c(C)cccc4N)cc3n(CCCN3CCN(C)CC3)c2=O)c1

nearest known ligand 0.64

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FGFR4 P22455 8/20 0.64
▸ FGFR1 P11362 8/20 0.48
▸ FGFR2 P21802 2/20 0.48
▸ FGFR3 P22607 2/20 0.48
▸ KDR P35968 1/20 0.48
▸ SRC P12931 8/20 0.46
▸ BTK Q06187 6/20 0.45
▸ LYN P07948 3/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30365563 0.88 FGFR4 (0.63) FGFR4FGFR1FGFR2FGFR3KDR
SCHEMBL28683029 0.88 FGFR4 (0.63) FGFR4FGFR1FGFR2FGFR3KDR
SCHEMBL25162435 0.85 FGFR4 (0.74) FGFR4FGFR1FGFR2FGFR3
SCHEMBL27428803 0.84 FGFR4 (0.60) FGFR4FGFR1FGFR2FGFR3SRC
SCHEMBL30365649 0.83 FGFR4 (0.60) FGFR4FGFR1FGFR2FGFR3SRC
SCHEMBL28699499 0.83 FGFR4 (0.60) FGFR4FGFR1FGFR2FGFR3SRC
SCHEMBL30365599 0.82 FGFR4 (0.62) FGFR4FGFR1FGFR2FGFR3SRC
SCHEMBL30365983 0.81 FGFR4 (0.68) FGFR4FGFR1FGFR2FGFR3KDR
SCHEMBL28679307 0.81 FGFR4 (0.68) FGFR4FGFR1FGFR2FGFR3KDR
SCHEMBL30365929 0.81 FGFR4 (0.70) FGFR4FGFR1FGFR2FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4393921-A1 NALIDINONE COMPOUND AS FGFR4 INHIBITOR AND USE THEREOF Wenzhou Medical University (CN) 2024-07-03 — — EP disclosed