Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 6/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL27429811 | 0.87 | TNF (0.46) | TNFACHEALOX5EPHX2BRD4 | |
| SCHEMBL27424435 | 0.85 | TNF (0.47) | TNFACHEALOX5EPHX2BRD4 | |
| SCHEMBL16495220 | 0.78 | MAPT (0.46) | TNFACHEALOX5EPHX2BRD4 | |
| SCHEMBL9029844 | 0.78 | HDAC1 (0.48) | ACHE | |
| SCHEMBL16495315 | 0.77 | PRMT1 (0.48) | TNFACHEMEN1KMT2A | |
| SCHEMBL16495164 | 0.77 | HDAC1 (0.44) | TNFACHEALOX5EPHX2 | |
| SCHEMBL16495267 | 0.76 | MAPT (0.47) | TNFALOX5EPHX2 | |
| SCHEMBL16495305 | 0.76 | TNF (0.48) | TNFACHEALOX5EPHX2BRD4 | |
| SCHEMBL16495221 | 0.76 | MAPT (0.45) | TNFACHEALOX5EPHX2EGFR | |
| SCHEMBL9422707 | 0.76 | ALOX5 (0.56) | TNFALOX5EPHX2EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085894-A | The indolinyl N-hydroxyurea of anti-inflammatory and N-hydroxamic acid derivs | PFIZER (US) | 1994-04-27 | — | — | CN | disclosed |