Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004811 | 0.85 | KIT (0.41) | TRPV1HRH4MAPK13MAPK12MAPK11 | |
| SCHEMBL8339118 | 0.81 | BPTF (0.50) | TRPV1HRH4ALDH1A1BPTFHTR2A | |
| SCHEMBL13407135 | 0.77 | TRPV1 (0.52) | TRPV1HRH4BPTF | |
| SCHEMBL1140803 | 0.76 | HRH4 (0.40) | HRH4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1140801 | 0.76 | HRH4 (0.40) | HRH4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18081052 | 0.75 | ALDH1A1 (0.45) | HRH4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18038795 | 0.75 | ALDH1A1 (0.45) | HRH4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL18038793 | 0.75 | ALDH1A1 (0.45) | HRH4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20135002 | 0.75 | KIT (0.43) | HRH4MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL29688471 | 0.75 | KIT (0.43) | HRH4MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434721-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2016-09-06 | — | — | US | disclosed |
| US-9434721-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2016-09-06 | — | — | US | disclosed |
| US-20140142112-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140142112-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2014-05-22 | — | — | US | disclosed |
| US-8536177-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536177-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20120015954-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015954-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120004217-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2012-01-05 | — | — | US | disclosed |
| US-20120004217-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2012-01-05 | — | — | US | disclosed |
| US-8008300-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2011-08-30 | — | — | US | disclosed |
| US-8008300-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100004254-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004254-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2010-01-07 | — | — | US | disclosed |
| US-7582635-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA, L.P. | 2009-09-01 | — | — | US | disclosed |
| EP-1583763-B1 | BENZOAZOLYLPIPERAZINE DERIVATIVES HAVING VR1-ANTAGONIST ACTIVITY | EURO CELTIQUE SA (LU) | 2008-03-26 | — | — | EP | disclosed |
| WO-2004058754-A1 | BENZOAZOLYPIPERAZINE DERIVATIVES HAVING MGLUR1- AND MGLUR5-ANTAGONISTIC ACTIVITY | EURO-CELTIQUE S.A. (LU) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015954-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | CDR2, GRIN1, HRH2 | TRPV1 287/4885HRH4 14/4885MAPK13 2539/4885 |
| US-20100004254-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | CDR2, GRIN1, HRH2 | TRPV1 287/4885HRH4 14/4885MAPK13 2539/4885 |
| US-20140142112-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | CDR2, GRIN1, HRH2 | TRPV1 287/4885HRH4 14/4885MAPK13 2539/4885 |
| US-20120004217-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | CDR2, GRIN1, HRH2 | TRPV1 287/4885HRH4 14/4885MAPK13 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.