Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 5/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461158 | 0.91 | GRIN1 (0.53) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| SCHEMBL28213508 | 0.86 | GRIN1 (0.54) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL28039604 | 0.84 | GRIN1 (0.53) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| SCHEMBL27690833 | 0.78 | OPRM1 (0.53) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| SCHEMBL30567984 | 0.75 | SLC6A4 (0.47) | GRIN1GRIN2ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL7245634 | 0.74 | HTR2A (0.44) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| SCHEMBL29082026 | 0.72 | GRIN1 (0.47) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL7925631 | 0.71 | CYP2D6 (0.41) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL7934514 | 0.71 | OPRM1 (0.44) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL29082373 | 0.70 | GRIN1 (0.46) | GRIN1GRIN2AGRIN2BOPRM1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1126471-A | Tetrazole derivatives | SUMITOMO METAL IND (JP) | 1996-07-10 | — | — | CN | disclosed |