Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27905866 | 0.82 | CYP1A2 (0.48) | NPC1TYMPKDM4EHPGDHSD17B10 | |
| SCHEMBL6699250 | 0.80 | NPC1 (0.43) | NPC1JAK2THRBTYMPKDM4E | |
| SCHEMBL62885 | 0.77 | NPSR1 (0.50) | NPC1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL71362 | 0.75 | NOTUM (0.48) | KDM4EGAAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL10962665 | 0.74 | JAK2 (0.59) | NPC1JAK2THRBTYMPKDM4E | |
| SCHEMBL8545504 | 0.74 | HPGD (0.56) | NPC1THRBKDM4EHPGDHSD17B10 | |
| SCHEMBL11802081 | 0.73 | NOTUM (0.43) | NPC1JAK2KDM4EGAAHPGD | |
| SCHEMBL1060549 | 0.73 | TYMP (0.46) | NPC1JAK2THRBTYMPKDM4E | |
| SCHEMBL31653960 | 0.73 | KDM4E (0.44) | NPC1THRBKDM4EGAAHPGD | |
| SCHEMBL30786868 | 0.73 | JAK2 (0.52) | NPC1JAK2THRBTYMPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1105353-A | Modular design and synthesis of oxazolone-derived molecules | ARQULE PARTNERS L P (US) | 1995-07-19 | — | — | CN | disclosed |