Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545504 | 0.81 | HPGD (0.56) | ALDH1A1KMT2ALMNAPOLBCYP1A2 | |
| SCHEMBL7252333 | 0.78 | SMN1; SMN2 (0.45) | NPSR1NR4A2ALDH1A1KMT2ALMNA | |
| SCHEMBL27905866 | 0.77 | CYP1A2 (0.48) | NPSR1ALDH1A1KMT2ACYP1A2L3MBTL1 | |
| SCHEMBL27436337 | 0.77 | NPC1 (0.48) | NPSR1ALDH1A1KMT2ALMNACYP1A2 | |
| SCHEMBL7250696 | 0.76 | USP2 (0.40) | NPSR1NR4A2ALDH1A1KMT2ALMNA | |
| SCHEMBL6699250 | 0.75 | NPC1 (0.43) | NPSR1ALDH1A1KMT2APOLBCYP1A2 | |
| SCHEMBL5419895 | 0.75 | GAA (0.46) | NPSR1NR4A2ALDH1A1KMT2ALMNA | |
| SCHEMBL13488596 | 0.72 | NPSR1 (0.66) | NPSR1NR4A2ALDH1A1KMT2ALMNA | |
| SCHEMBL12364192 | 0.72 | L3MBTL1 (0.46) | NPSR1ALDH1A1KMT2ALMNACYP1A2 | |
| SCHEMBL7290595 | 0.71 | NPSR1 (0.53) | NPSR1NR4A2ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230295171-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | WELLS THERAPEUTICS, INC. | 2023-09-21 | — | — | US | disclosed |
| US-20220306634-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | TAKEDA SAN DIEGO, INC. | 2022-09-29 | — | — | US | disclosed |
| EP-4019518-A1 | TYK2 INHIBITORS AND USES THEREOF | Nimbus Lakshmi, Inc. (US) | 2022-06-29 | — | — | EP | disclosed |
| EP-3110820-B1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI INC (US) | 2022-04-06 | — | — | EP | disclosed |
| EP-3825316-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2021-05-26 | — | — | EP | disclosed |
| EP-3825316-A1 | FUSED HETEROAROMATIC PYRROLIDINONES AS SYK INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2021-05-26 | — | — | EP | disclosed |
| EP-3489236-B1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-30 | — | — | EP | disclosed |
| EP-3489236-B1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | TAKEDA PHARMACEUTICALS CO (JP) | 2020-09-30 | — | — | EP | disclosed |
| EP-3489236-A1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | Takeda Pharmaceutical Company Limited (JP) | 2019-05-29 | — | — | EP | disclosed |
| EP-3489236-A1 | PROCESS FOR THE PREPARATION OF FUSED HETEROAROMATIC PYRROLIDINONES | Takeda Pharmaceutical Company Limited (JP) | 2019-05-29 | — | — | EP | disclosed |
| CN-1890263-A | Tumour suppressor protein | LUDWIG INST CANCER RES (CH) | 2007-01-03 | — | — | CN | disclosed |
| CN-1890385-A | Genes associated with colorectal cancer | UNIV SHEFFIELD (GB) | 2007-01-03 | — | — | CN | disclosed |
| CN-1860242-A | Self-hybridizing multiplex target nucleic acid probes and methods of use thereof | DYNAL BIOTECH INC (US) | 2006-11-08 | — | — | CN | disclosed |
| US-20050277654-A1 | 4,5-Disubstituted-2-aryl pyrimidines | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2005-12-15 | — | — | US | disclosed |
| WO-2005110416-A2 | 4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES | NEUROGEN CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |
| CN-1628168-A | Methods and materials for the production of organic products in cells of dollar i(candida) species | CARGILL DOW POLYMERS LLC (US) | 2005-06-15 | — | — | CN | disclosed |
| CN-1575340-A | Compositions and methods for treating neurodegenerative diseases | TANABE SEIYAKU CO (JP) | 2005-02-02 | — | — | CN | disclosed |
| CN-1566366-A | Genotype assignment method based on DNA chip and use thereof | UNIV TSINGHUA (CN) | 2005-01-19 | — | — | CN | disclosed |
| CN-1463270-A | Cytotoxins, prodrugs, linkers and stabilizers useful therefor | MEDAREX INC (US) | 2003-12-24 | — | — | CN | disclosed |
| CN-1171112-A | Amino acid nucleic acids | ICN PHARMACEUTICALS CO (US) | 1998-01-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050277654-A1 | 4,5-Disubstituted-2-aryl pyrimidines | C5AR2, C3AR1, C5AR1 | NPSR1 220/4885NR4A2 241/4885ALDH1A1 1616/4885 |
| US-20220306634-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | SYK, ZAP70, LYN | NPSR1 1144/4885NR4A2 1928/4885ALDH1A1 824/4885 |
| US-20230295171-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | SYK, ZAP70, LYN | NPSR1 1144/4885NR4A2 1928/4885ALDH1A1 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.