Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22533835 | 0.81 | CYP11B1 (0.41) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL22547863 | 0.79 | FGFR1 (0.43) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL22533730 | 0.78 | PNP (0.50) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL22547180 | 0.74 | HTR2C (0.48) | EGLN1 | |
| SCHEMBL22533846 | 0.73 | NR1H4 (0.41) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL12894977 | 0.72 | HTR2A (0.40) | SMN1; SMN2LMNABRD4TSHRALDH1A1 | |
| SCHEMBL3245588 | 0.68 | TLR8 (0.49) | LMNATSHRALDH1A1KDM4E | |
| SCHEMBL22547166 | 0.68 | MEN1 (0.51) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL7672864 | 0.67 | CYP11B1 (0.75) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 | |
| SCHEMBL17596372 | 0.67 | CYP11B1 (0.55) | CYP11B1CYP11B2HTTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | RIBOSCIENCE LLC (US) | 2024-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12029744-B2 | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | ENPP1, ENPP3, SMPD1 | CYP11B1 127/4885CYP11B2 166/4885HTT 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.