Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.76 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.76 |
| ▸ | STAT3 | P40763 | 1/20 | 0.76 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.76 |
| ▸ | RELA | Q04206 | 1/20 | 0.76 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.76 |
| ▸ | APP | P05067 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.67 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.67 |
| ▸ | TUBB | P07437 | 1/20 | 0.67 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.67 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.67 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.67 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.67 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.67 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744728 | 1.00 | NFKB1 (0.76) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL2744663 | 0.95 | NFKB1 (0.74) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL2744668 | 0.95 | NFKB1 (0.74) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL27974543 | 0.92 | TUBB1 (0.77) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL27974391 | 0.91 | BACE1 (0.80) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL3337939 | 0.91 | CYP1A2 (0.63) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL3337937 | 0.91 | CYP1A2 (0.63) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL14008360 | 0.90 | NFKB1 (0.62) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL14035464 | 0.90 | NFKB1 (0.62) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 | |
| SCHEMBL608770 | 0.89 | BACE1 (0.70) | NFKB1CYP1A2CYP2D6ALOX5HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | SHIBATA, HIROYUKI (JP) | 2010-06-17 | — | — | US | claimed |
| US-8178727-B2 | Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer | NATIONAL UNIVERSITY CORPORATION TOHOKU UNIVERSITY (JP) | 2012-05-15 | — | — | US | disclosed |
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | SHIBATA, HIROYUKI (JP) | 2010-06-17 | — | — | US | disclosed |
| US-5466397-A | Polyethers, epoxy resins, polycarbonates | THE DOW CHEMICAL COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152493-A1 | BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER | MYC, CCNE2, CCNE1 | NFKB1 328/4885CYP1A2 1717/4885CYP2D6 1871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.