Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 10/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.59 |
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | STAT1 | P42224 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMO | Q99835 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27452867 | 0.83 | HDAC1 (0.69) | MAPTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL38652239 | 0.83 | HDAC1 (0.62) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6331116 | 0.81 | NPC1 (0.58) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL27451638 | 0.80 | MAPT (0.64) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL14106378 | 0.79 | KMT2A (0.69) | MAPTSMN1; SMN2KDM4ELMNAMEN1 | |
| SCHEMBL24359341 | 0.79 | HDAC1 (0.77) | MAPTRAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL27452892 | 0.79 | NAMPT (0.53) | MAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL27452355 | 0.77 | MAPT (0.63) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL27452350 | 0.77 | ADORA2A (0.48) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL14106363 | 0.74 | MEN1 (0.57) | MAPTSMN1; SMN2KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024145662-A1 | 2-SUBSTITUTED THIAZOLE AND BENZOTHIAZOLE COMPOSITIONS AND METHODS AS DUX4 INHIBITORS | ALTAY THERAPEUTICS, INC. (US) | 2024-07-04 | — | — | WO | disclosed |