Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.63 |
| ▸ | JAK1 | P23458 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746305 | 0.91 | SYK (0.61) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2746085 | 0.85 | SYK (0.51) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2745787 | 0.85 | SYK (0.51) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2746290 | 0.85 | SYK (0.72) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL658794 | 0.84 | SYK (0.71) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2745854 | 0.82 | SYK (0.51) | SYKJAK2EGFRLCKLYN | |
| SCHEMBL658283 | 0.82 | SYK (0.73) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2105664 | 0.82 | SYK (0.73) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2785795 | 0.82 | SYK (0.73) | SYKJAK1JAK3JAK2EGFR | |
| SCHEMBL2102238 | 0.81 | SYK (0.67) | SYKJAK1JAK3JAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178671-B2 | Ring attached at N2 and N4 of 2,4-pyrimidinediamines; for treating rheumatoid arthritis; N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | claimed |