Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.72 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745313 | 0.93 | SYK (0.62) | SYKJAK1JAK3EGFR | |
| SCHEMBL2746000 | 0.93 | SYK (0.67) | SYKJAK1JAK3EGFRJAK2 | |
| SCHEMBL2745650 | 0.86 | SYK (0.56) | SYKEGFR | |
| SCHEMBL2745158 | 0.86 | SYK (0.58) | SYKJAK1JAK3EGFR | |
| SCHEMBL2746305 | 0.85 | SYK (0.61) | SYKJAK1JAK3EGFRJAK2 | |
| SCHEMBL2745738 | 0.85 | SYK (0.72) | SYKJAK1JAK3EGFRJAK2 | |
| SCHEMBL2745787 | 0.85 | SYK (0.51) | SYKJAK1JAK3EGFRJAK2 | |
| SCHEMBL2745854 | 0.85 | SYK (0.51) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2745338 | 0.85 | SYK (0.63) | SYKJAK1JAK3EGFRJAK2 | |
| SCHEMBL2746085 | 0.85 | SYK (0.51) | SYKJAK1JAK3EGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178671-B2 | Ring attached at N2 and N4 of 2,4-pyrimidinediamines; for treating rheumatoid arthritis; N4-(2,2-dimethyl-3-oxo-4H-5-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine | RIGEL PHARMACEUTICALS, INC. (US) | 2012-05-15 | — | — | US | claimed |